The 8th session "Beyond organ transplantation" was opened by John Jackon (Wake Forest Institute for Regent Medicine, USA). Speaker told about characterization of decellularized thymus scaffolds for use in engineering thymus tissue. It is known that the thymus undergoes a process of involution associated with the T cells decreasing during evolution. In order to solve these aging problem the group of scientists have developed a an engineered thymus that may provide a method to increase the number of naive mature T cells and to enhance immune responses to pathogens.In addition the main target of this project is to create a thymus by developing decellurazitation protocols to produce natural scaffolds having the potential to support the production of a functional thymus.
Eric Lagasse (McGowan Institute for Regenerative Medicine ) reported about the еctopic organogenesis in lymph node. So,one of the main goal in order to prevent health crisis associated with aged organs is to grow tissues and organs in the lab. Scientist supposed the concept that certain locations in the body may be amenable to in vivo tissue and organ regeneration.And in addition to above it has been hypothesized that the lymph node (LN) offers a rich environment not only to the lymphocytes but also to the variety of tumor cells by creating a new form of tumor mass that is appropriate to this target.It is an mysterious fact and by the way it is needed a well advanced methodology for the future ectopic and organ regeneration.
Steve Van Sickle offered an improved technology for organ cryopreservation by vitrification.
The desire to create the safe organs storage is limited by the well improved method presence. By the way it has been developed a new technology which is able to eliminate fracturing and reduce the effective toxicity of verifiable cryoprotectants.
The 9th session"Cellular regeneration" was begun by the Robin Franklin(Cambridge University, UK)
project presentation according to myelin regeneration and ageing. Scientist paid an attention to the recent studies aimed to obtaining a detailed understanding of the mechanisms of regulating differentiation during remyelination and hence identifying novel therapeutic targets.
Graca Almeida-Porada(Wake Forest Institute for Regenerative Medicine, USA) reported a project according to engineering stem cells for liver and gut regeneration. It was discussed the viral proteins usage in order to enhance the inherent immune privilege by these cells and by the way to improve their survaival and therapeutic abilities in allogeneic settings.
Malcolm Maden (University of Florida) finished this session by the exciting question "Regeneration in adult organisms -a cure for ageing"? Speaker discovered an abillity of retinoic acid to induce regeneration in mammalian organs such as luns and spinal cord which normally luck this opportunities. So it is needed more experiments in order to be sure about the retinoic acid properties.
The 10th session "SENS Lecture an short talks" was began by George Church report about technologies for reading, writing and unterpreting omes. In order to study and analyze the variable data such as human diplotypes, immunosomes, microbiomes and etc. It is needed an advanced medicine requires and also we need next-generation human genome and epi-genome engineering using CRISPR by minimizing off-targeting and maximizing multiplexing.
Justin Rebo discussed about treating cytopenia with ESC derived blood cells The main problem in order to get a big amount of the blood cell progenitors is a very limited bone marrow supply, while production of these cells would have a great clinical benefit.The attempts to receive blood cells progenitors from ESCs have met a fail: the derived progenitors lacked bone marrow homing ability when transplanted into irradiated mice and didn't protect mice from myelotoxicity.On this account the scientific group developed a novel differentiation process to address these problems.Thus, they produced hematopoietic-colony-forming cells that express CXCR4,the receptor for SDF-1 and key mediator the bone marrow homing pathway,without using any genetic manipulation. In addition they showed that these cells home to the bone marrow and increased survival in mice with cytotoxic induced cytopenia.
Another disturbing problem associated with cardiac diseases.In view of these James Larick (Panorama Research Institute,USA) and his colleagues suppose that the augmented Sodium-Potasium ATPASE (NKA) activity is correlated with a positive cardiotonic action and perhaps most importantly activation cardioprotective pathways in vivo.
Eric Lagasse (McGowan Institute for Regenerative Medicine ) reported about the еctopic organogenesis in lymph node. So,one of the main goal in order to prevent health crisis associated with aged organs is to grow tissues and organs in the lab. Scientist supposed the concept that certain locations in the body may be amenable to in vivo tissue and organ regeneration.And in addition to above it has been hypothesized that the lymph node (LN) offers a rich environment not only to the lymphocytes but also to the variety of tumor cells by creating a new form of tumor mass that is appropriate to this target.It is an mysterious fact and by the way it is needed a well advanced methodology for the future ectopic and organ regeneration.
Steve Van Sickle offered an improved technology for organ cryopreservation by vitrification.
The desire to create the safe organs storage is limited by the well improved method presence. By the way it has been developed a new technology which is able to eliminate fracturing and reduce the effective toxicity of verifiable cryoprotectants.
The 9th session"Cellular regeneration" was begun by the Robin Franklin(Cambridge University, UK)
project presentation according to myelin regeneration and ageing. Scientist paid an attention to the recent studies aimed to obtaining a detailed understanding of the mechanisms of regulating differentiation during remyelination and hence identifying novel therapeutic targets.
Graca Almeida-Porada(Wake Forest Institute for Regenerative Medicine, USA) reported a project according to engineering stem cells for liver and gut regeneration. It was discussed the viral proteins usage in order to enhance the inherent immune privilege by these cells and by the way to improve their survaival and therapeutic abilities in allogeneic settings.
Malcolm Maden (University of Florida) finished this session by the exciting question "Regeneration in adult organisms -a cure for ageing"? Speaker discovered an abillity of retinoic acid to induce regeneration in mammalian organs such as luns and spinal cord which normally luck this opportunities. So it is needed more experiments in order to be sure about the retinoic acid properties.
The 10th session "SENS Lecture an short talks" was began by George Church report about technologies for reading, writing and unterpreting omes. In order to study and analyze the variable data such as human diplotypes, immunosomes, microbiomes and etc. It is needed an advanced medicine requires and also we need next-generation human genome and epi-genome engineering using CRISPR by minimizing off-targeting and maximizing multiplexing.
Justin Rebo discussed about treating cytopenia with ESC derived blood cells The main problem in order to get a big amount of the blood cell progenitors is a very limited bone marrow supply, while production of these cells would have a great clinical benefit.The attempts to receive blood cells progenitors from ESCs have met a fail: the derived progenitors lacked bone marrow homing ability when transplanted into irradiated mice and didn't protect mice from myelotoxicity.On this account the scientific group developed a novel differentiation process to address these problems.Thus, they produced hematopoietic-colony-forming cells that express CXCR4,the receptor for SDF-1 and key mediator the bone marrow homing pathway,without using any genetic manipulation. In addition they showed that these cells home to the bone marrow and increased survival in mice with cytotoxic induced cytopenia.
Another disturbing problem associated with cardiac diseases.In view of these James Larick (Panorama Research Institute,USA) and his colleagues suppose that the augmented Sodium-Potasium ATPASE (NKA) activity is correlated with a positive cardiotonic action and perhaps most importantly activation cardioprotective pathways in vivo.
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